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Phentermine commonly causes insomnia and restlessness due to its stimulant properties, while tirzepatide commonly causes fatigue and low energy, particularly during dose escalation
10.1038/s41598-021-95117-0 19 BrvbaM.SilamieleL.KalniaI.SilamielisI.BirznieceL.AnsoneL.et al (2023)
It triggers pulsatile GH release without substantially increasing ACTH or cortisol in preclinical work, and has been investigated in human trials for safety in specific clinical settings
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PMID 19754465
These include its actions on acetylcholine synthesis, membrane stability, nerve growth factor production, and cerebral blood flow
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